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    Randy S. D'Amico, MD

    Physician
    Lenox Hill Department of Neurosurgery

    Randy S. D’Amico, MD, is a neurosurgeon at Lenox Hill Hospital and Northwell Health whose work sits at the intersection of complex cranial surgery, neuro-oncology, and emerging neurotechnologies. He specializes in the treatment of primary and metastatic brain tumors, with a particular focus on how structural and functional network architecture—connectomics—can be incorporated into surgical planning, intraoperative decision-making, and postoperative recovery.

    Dr. D’Amico serves as Director of the Brain and Spine Metastasis Program, where he leads multidisciplinary efforts to improve outcomes for patients with metastatic disease through optimized workflows, high-quality surgical care, precision radiation strategies, and innovative systemic therapy collaborations. His programmatic work emphasizes efficiency, access, and data-informed quality measures that directly impact patient experience and longitudinal outcomes.

    His academic work centers on functional network integrity in brain tumor patients. He has published and lectured widely on glioma connectomics, resting-state fMRI, quantitative tractography, and network-based predictors of cognitive recovery. He is currently leading several institutional and multi-site research initiatives, including trials integrating advanced connectomics imaging for monitoring tumor progression, assessing treatment response, and guiding resection strategy. His group has also developed novel metrics—such as the Disconnection Burden Score and Compensatory Index—to quantify network disruption and adaptation across the course of disease and recovery.

    A committed educator and collaborator, Dr. D’Amico is actively involved in national neurosurgical education and mentorship. He contributes to multiple scientific manuscripts, systematic reviews, and book chapters each year. He is a frequent reviewer for neurosurgical journals and a regular faculty member for educational programs focused on neuro-oncology, advanced mapping, and minimally invasive cranial surgery. He also leads digital education efforts including Tumor Talk and BRAINterns.

    Dr. D’Amico’s clinical and research portfolio is complemented by work in surgical innovation. He is interested in advancing augmented reality, spatial computing, computer vision, fluorescence-guided surgery, and intraoperative imaging. His goal is to bridge the gap between cutting-edge technology and real-world surgical needs, ensuring that innovation remains tied to practical improvement in patient care.

    Across the operating room, the research lab, and the digital sphere, Dr. D’Amico’s work is united by a single goal: bringing precision, humanity, and clarity to the care of patients facing brain and spine tumors. He is widely regarded for his collaborative approach, clear communication, and ability to translate complex science into meaningful clinical impact.

    Disclosure(s): Medivis: Consultant (Ongoing); olympus: Consultant (Ongoing); Omniscient neurotechnology: Consultant (Ongoing)

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